21-P036 Signaling in development – Unravelling engrailed1 function in mesodiencephalic dopaminergic (mdDA) neurons
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چکیده
منابع مشابه
21-P036 Signaling in development – Unravelling engrailed1 function in mesodiencephalic dopaminergic (mdDA) neurons
The mesodiencephalic dopaminergic (mdDA) system is involved in the control of movement and behavior. These neurons are located in three distinct nuclei in the midbrain, one of which is the substantia nigra pars compacta (SN). The loss of dopaminergic neurons in this neuronal population is the neuropathological hallmark of Parkinson’s disease (PD). The homeobox transcription factor engrailed 1 (...
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The LIM homeodomain transcription factor Lmx1a is a very potential inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of this gene, the exact in vivo role of Lmx1a in mesodiencephalic dopamine (mdDA) neuronal specification is still not understood. To analyze the genes functioning downstream of Lmx1a, we performed expression microarray analysis of LMX1A o...
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Studying the development of mesodiencephalic dopaminergic (mdDA) neurons provides an important basis for better understanding dopamine-associated brain functions and disorders and is critical for establishing cell replacement therapy for Parkinson's disease. The transcription factors Otx2 and Lmx1b play a key role in the development of mdDA neurons. However, little is known about the genes down...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.901